Research Progress on the Role of Autophagy Pathway in the Pharmacological Treatment of Multiple Myeloma——Review

VernacularTitle:自噬途径在药物治疗多发性骨髓瘤中作用的研究进展
Author: Wei WANG ¹ ; Qing ZHANG ; Zhi-Hua ZHANG
Author Information

1. 承德医学院附属医院血液内科,河北承德 067000
Keywords: multiple myeloma; autophagy; drug therapy; apoptosis
From: Journal of Experimental Hematology 2024;32(5):1618-1621
CountryChina
Language:Chinese
Abstract: Multiple myeloma(MM)is a malignant hematological tumour for which pharmacological treatments such as protease inhibitors,immunomodulators,and steroids are commonly used,but most MM cases still relapsed or become refractory.Autophagy is a type 2 cell death mechanism that plays a key role in MM progression,including biphasic regulation that promotes MM cell survival or facilitates its death.In this paper,we review the changes of MM cells'autophagic activity and its effect on cell proliferation and apoptosis during drug action,aiming to analyse the role of autophagy pathway in drug treatment of MM and provide relevant ideas for targeting autophagy in the treatment of MM.