Cytokines and Myeloproliferative Neoplasms:Current Research Status from Mechanism to Clinic——Review

VernacularTitle:细胞因子与骨髓增殖性肿瘤:从机制到临床的研究现状
Author: Ye-Chao TU ¹ ; Shi-Xuan WANG ; Fei LI
Author Information

1. 南昌大学第一附属医院血液病中心;江西省血液病临床医学研究中心;南昌大学淋巴肿瘤疾病研究所,江西南昌 330006
Keywords: myeloproliferative neoplasms; cytokines; inflammation; symptoms
From: Journal of Experimental Hematology 2024;32(5):1608-1613
CountryChina
Language:Chinese
Abstract: Myeloproliferative neoplasms(MPN)are a group of malignant myeloid tumors caused by hematopoietic stem cell proliferation.The discovery of gene mutations has elucidated the pathogenesis of MPN and provided molecular diagnostic criteria for MPN.Recent studies have shown that there are cytokine disorders in MPN patients,and the changes in the microenvironment caused by these cytokine disorders may have great significance for the pathophysiology and pathogenesis of MPN,which may lead to corresponding clinical symptoms and different prognosis in patients.In this review,the latest research progress on the role and status of cytokines in MPN will be summarized.