Effect and Influencing Factors of Peripheral Blood Hematopoietic Stem Cells Collection from Unrelated Donors
10.19746/j.cnki.issn1009-2137.2024.05.039
- VernacularTitle:非血缘供者外周血造血干细胞采集效果及其影响因素分析
- Author:
Huan YANG
1
;
Yu TANG
;
Hua SUN
;
Hong-Xia XIANG
Author Information
1. 岳阳市中心医院血液内科,湖南岳阳 414000
- Keywords:
unrelated donors;
collection of peripheral blood hematopoietic stem cells;
affecting factors
- From:
Journal of Experimental Hematology
2024;32(5):1555-1559
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the effect of peripheral blood hematopoietic stem cells(PBSC)collection from unrelated donors and its influencing factors.Methods:A retrospective analysis was conducted on the mobilization and collection of PBSC from 113 unrelated donors at Yueyang Central Hospital from January 2021 to December 2023.Results:113 donors were successfully mobilized.The average count of PBSC mononuclear cells(MNC)and CD34+cells were(12.40±7.41)x 108/kg and(10.64±8.07)x 106/kg,respectively.Univariate analysis showed that the PBSC CD34+cells ratio of male donors was significantly higher than that in female donors(P=0.015).The peripheral blood(PB)white blood cell(WBC)count before collection was positively correlated with the PBSC nucleated cells count(r=0.388),and the donor's body weight,the PB CD34+cell ratio before collection were positively correlated with the PBSC CD34+cell ratio(r=0.259,r=0.780).The daily dose of rhG-CSF was negatively correlated with the PBSC CD34+cell ratio(r=-0.285).Both rhG-CSF agents achieved successful mobilization.Multivariate analysis showed that PB WBC count before collection was a factor affecting the count of PBSC nucleated cells(P＜0.001),while the PB CD34+cell ratio before collection was a factor affecting the PBSC CD34+cell ratio(P＜0.001).Conclusion:The mobilization and collection of PBSC from unrelated donors are good,and the PB WBC count and CD34+cell ratio before collection are reliable indicators for predicting the collection effect.
