Analysis of Factors Influencing Overall Survival and Prognosis of AML Patients Over 50 Years Old
10.19746/j.cnki.issn1009-2137.2024.04.010
- VernacularTitle:50岁以上AML患者总体生存及预后影响因素分析
- Author:
Hong LIU
1
;
Zhi LI
;
Yu-Ye SHI
;
Shan-Dong TAO
;
Chun-Ling WANG
;
Liang YU
Author Information
1. 南京医科大学附属淮安第一医院血液科
- Keywords:
acute myeloid leukemia;
overall survival;
prognostic factors;
gene mutation
- From:
Journal of Experimental Hematology
2024;32(4):1039-1045
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the overall survival and prognostic factors of patients over 50 years old with acute myeloid leukemia(AML).Methods:The clinical data of 222 AML patients aged over 50 years in our hospital from January 2016 and June 2021 were retrospectively analyzed.Kaplan-Meier method was used to evaluate the overall survival(OS)rate,and Cox regression model to evaluate the prognostic factors.Results:The 1-year and 3-year OS rates of all patients were 46.8％and 28.8％,respectively.The recurrence rate of patients who achieved remission during follow-up time was 57％.Both univariate and multivariate analysis showed that advanced age,MLL family fusion gene,PHF6 gene mutation,TP53 gene mutation,intolerance to standard chemotherapy,incomplete remission,complex karyotype,+mar karyotype and inv(3)karyotype were significantly correlated with prognosis(all P＜0.05).Negative fusion gene and positive AML-ETO fusion gene had no obvious survival advantage in this population.In patients with complete remission,there was no significant survival advantage in those who achieved minimal residual disease negative.Conclusion:AML patients aged over 50 years have a poor outcome and high recurrence rate.The prognosis is affected by multiple factors and has its own characteristics.
