Changes in Serum HOXA9,PCⅢ,SE-CAD Levels in AML Patients after Chemotherapy with DCAG Regimen and Their Relationship with Prognosis
10.19746/j.cnki.issn1009-2137.2024.04.002
- VernacularTitle:经DCAG方案化疗后AML患者血清HOXA9、PCⅢ、SE-CAD水平的变化及其与预后的关系
- Author:
Huan SU
1
;
Ning WEN
;
Jie XIANG
;
Neng-Yong WANG
Author Information
1. 广元市中心医院检验科,四川广元 628400
- Keywords:
acute myeloid leukemia;
homobox A9;
soluble E-cadherin;
type Ⅲ procollagen;
DCAG chemotherapy regimen
- From:
Journal of Experimental Hematology
2024;32(4):987-992
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the changes in serum homeobox A9(HOXA9),soluble E-cadherin(SE-CAD)and type Ⅲ procollagen(PCⅢ)levels in acute myeloid leukemia(AML)patients after chemotherapy with DCAG regimen and their relationship with prognosis.Methods:The clinical data of 80 patients with relapsed/refractory AML diagnosed and treated in our hospital from March 2018 to December 2021 were retrospectively analyzed.According to different treatment regimen,the patients were divided into DCAG group(n=40)and CAG group(n=40).The clinical efficacy and changes of HOXA9,SE-CAD and PCⅢ levels before and after treatment were compared.In addition,all patients were divided into remission group(n=58)and non-remission group(n=22)according to the clinical efficacy.Univariate and multivariate analyses were performed to analyze the risk factors affecting the prognosis of AML patients.The predictive efficacy of the three single indicators,HOXA9,SE-CAD,and PC Ⅲ,and their combination on prognosis was analyzed.Results:Compared with before treatment,the levels of HOXA9,SE-CAD and PCⅢ in both the DCAG and CAG groups were decreased after treatment,and the improvement of each indicator and the clinical efficacy in the DCAG group were significantly better than those in the CAG group(all P＜0.05).Multivariate analysis showed that increased bone marrow blast count,HOXA9 mRNA,SE-CAD and PCⅢ levels were independent risk factors affecting the efficacy of chemotherapy in AML patients(all P＜0.05).ROC curves showed that the combination of HOXA9 mRNA,SE-CAD and PCⅢ could effectively predict the prognosis of AML patients,with a sensitivity of 84.80％and a specificity of 88.20％.Conclusion:DCAG regimen can significantly improve the levels of HOXA9 mRNA,SE-CAD and PCⅢ in AML patients,these three indicators are all independent risk factors affecting the prognosis of AML patients,and the combination of the three indicators can effectively predict the prognosis of the patients.
