Target Selection of CAR-T Therapy in Acute Myeloid Leukemia——Review
10.19746/j.cnki.issn1009-2137.2024.03.049
- VernacularTitle:急性髓系白血病CAR-T治疗的靶点选择
- Author:
Ruo-Nan SHAO
1
;
Hong-Lei XIN
;
Xiao-Feng SHI
Author Information
1. 南京医科大学第二附属医院血液科,江苏南京 212100
- Keywords:
acute myeloid leukemia;
chimeric antigen receptor T cells;
targeted therapy
- From:
Journal of Experimental Hematology
2024;32(3):965-969
- CountryChina
- Language:Chinese
-
Abstract:
Chimeric antigen receptor(CAR)T cell therapy,one of the most promising tumor treatments,combines the targeted recognition of antigen and antibody with the killing effect of T cells.CAR-T has shown a strong therapeutic effect in lymphoid tumors and been applied in clinical practice.However,in the treatment of acute myeloid leukemia(AML),no effective and specific target like CD 19 in lymphoid tumors has been found.Therefore,the key research direction is to try multiple probabilities and use optimization strategies to enhance efficacy and reduce toxicity.This review introduces the latest research progress of AML targets in CAR-T therapy in recent years,analyzes the related problems that need to be solved at present,and summarizes the optimization construction strategies mentioned in the research.Hope it can provide reference for related research and clinical application of related product.
