Role of Telomere in Clonal Evolution of Acquired Aplastic Anemia——Review

VernacularTitle:端粒在获得性再生障碍性贫血克隆演化中的作用
Author: Dan-Ni LI ¹ ; Xian-Hao WEN
Author Information

1. 重庆医科大学附属儿童医院血液肿瘤科,儿童发育疾病研究教育部重点实验室,国家儿童健康与疾病临床医学研究中心,儿童发育重大疾病国家国际科技合作基地,儿科学重庆市重点实验室,重庆 400014
Keywords: telomere; acquired aplastic anemia; clonal evolution
From: Journal of Experimental Hematology 2024;32(3):962-964
CountryChina
Language:Chinese
Abstract: Studies have found that 1/3 patients with acquired aplastic anemia have shortened telomere length,and the shorter the telomere,the longer the disease course,the more prone to relapse,the lower the overall survival rate,and the higher the probability of clonal evolution.The regulation of telomere length is affected by many factors,including telomerase activity,telomerase-related genes,telomere regulatory proteins and other related factors.Telomere shortening can lead to genetic instability and increases the probability of clonal evolution in patients with acquired aplastic anemia.This article reviews the role of telomere in the clonal evolution of acquired aplastic anemia and factors affecting telomere length.