Research Progress on the Role of Berberine in Hematologic Malig-nancies and Its Related Mechanisms
10.19746/j.cnki.issn1009-2137.2024.02.048
- VernacularTitle:黄连素在血液肿瘤中的作用及相关机制研究进展
- Author:
Yong-Qin CAO
1
;
Chao SUN
;
Jian-Yong LI
;
Xin ZHOU
Author Information
1. 南京医科大学附属无锡市人民医院血液科,江苏无锡 214023
- Keywords:
berberine;
hematologic malignancies;
anticancer
- From:
Journal of Experimental Hematology
2024;32(2):639-642
- CountryChina
- Language:Chinese
-
Abstract:
Berberine,a traditional Chinese medicine,is an isoquinoline alkaloid extracted from the rhizome of Coptis chinensis.It has anti-inflammatory and antidiarrheal effects and is commonly used in the treatment of infections and gastrointestinal diseases.In recent years,studies have found that berberine can play a wide range of anti-cancer effects in the treatment of leukemia,lymphoma,multiple myeloma,etc.In hematologic malignancies,berberine can induce autophagy,promote apoptosis,regulate cell cycle,inhibit inflammatory response,cause oxidative damage to cancer cells and interact with miRNA to inhibit the proliferation,migration and colony formation of cancer cells.This paper will review the role and related mechanisms of berberine in hematological malignancies.
