Clinical Analysis of PEG-rhG-CSF in Mobilization of Autologous Hematopoietic Stem Cells in Hematological Tumors
10.19746/j.cnki.issn1009-2137.2024.02.035
- VernacularTitle:PEG-rhG-CSF在血液肿瘤自体造血干细胞动员中的临床分析
- Author:
Qing-Jiao CHEN
1
;
Xiao-Qiang ZHENG
Author Information
1. 福建医科大学附属第一医院血液科;福建医科大学附属第一医院滨海院区国家区域医疗中心血液科,福建省检验医学重点实验室,福建福州 350005
- Keywords:
autologous hematopoietic stem cell transplantation;
stem cell mobilization;
pegylated recombinant human granulocyte colony stimulating factor
- From:
Journal of Experimental Hematology
2024;32(2):556-560
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficiency and optimal time of stem cell apheresis mobilized by pegylated recombinant human granulocyte colony stimulating factor(PEG-rhG-CSF)in autologous stem cell transplantation(ASCT)for hematological malignancies without monitoring pre-collection CD34+cells.Methods:Forty-six patients underwent stem cell mobilization were retrospectively analyzed between August 2017 and January 2022 at the First Affiliated Hospital of Fujian Medical University.27 patients using high dose chemotherapy combined with PEG-rhG-CSF mobilization were enrolled in the PEG-rhG-CSF group,and other 19 patients mobilized with recombinant human granulocyte colony stimulating factor(G-CSF)were enrolled in G-CSF group.The mobilization and collection effects of the patients in two groups were compared.Results:A total of 46 patients underwent 86 apheresis procedures,the median amount of mononuclear cell(MNC)in the PEG-rhG-CSF group and G-CSF group was 6.54(3.85-12.61)× 108/kg and 6.15(1.13-11.58)× 108/kg,respectively(P＞0.05),the total CD34+cells of the grafts were 11.44(1.33-65.02)× 106/kg and4.95(0.30-24.02)× 106/kg(P＜0.05),with harvest timing of 14(10-20)days and 14(4-22)days,respectively(P＞0.05).In the PEG-rhG-CSF group,there was a significant difference between the number of CD34+cells collected when white blood cells(WBC)≥10 × 109/L and WBC＜10 × 109/L,19.04(2.85-65.02)×106/kg and 6.22(0.81-34.86)× 106/kg,respectively(P＜0.05).Conclusion:Stem cells mobilization with PEG-rhG-CSF was highly efficient with a median mobilization time of 14 days.In the absence of peripheral blood CD34 monitoring,peripheral blood WBC≥10 × 109/L can be considered as a threshold for a single stem cell apheresis to collect sufficient stem cells.
