Effects of total body irradiation-based conditioning on allogeneic stem cell transplantation for pediatric acute leukemia: a single-institution study.
10.3857/roj.2014.32.3.198
- Author:
Jongmoo PARK
1
;
Eun Kyung CHOI
;
Jong Hoon KIM
;
Sang Wook LEE
;
Si Yeol SONG
;
Sang Min YOON
;
Young Seok KIM
;
Su Ssan KIM
;
Jin Hong PARK
;
Jaehyeon PARK
;
Seung Do AHN
Author Information
1. Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. sdahn@amc.seoul.kr
- Publication Type:Original Article
- Keywords:
Total body irradiation;
Acute lymphoid leukemia;
Acute myeloid leukemia;
Child;
Stem cell transplantation
- MeSH:
Cataract;
Child;
Disease-Free Survival;
Graft vs Host Disease;
Humans;
Leukemia*;
Leukemia, Myeloid, Acute;
Mortality;
Nausea;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
Stem Cell Transplantation*;
Stem Cells;
Survival Rate;
Whole-Body Irradiation
- From:Radiation Oncology Journal
2014;32(3):198-207
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To evaluate the effects of total body irradiation (TBI), as a conditioning regimen prior to allogeneic stem cell transplantation (allo-SCT), in pediatric acute leukemia patients. MATERIALS AND METHODS: From January 2001 to December 2011, 28 patients, aged less than 18 years, were treated with TBI-based conditioning for allo-SCT in our institution. Of the 28 patients, 21 patients were diagnosed with acute lymphoblastic leukemia (ALL, 75%) and 7 were diagnosed with acute myeloid leukemia (AML, 25%). TBI was completed 4 days or 1 day before stem cell infusion. Patients underwent radiation therapy with bilateral parallel opposing fields and 6-MV X-rays. The Kaplan-Meier method was used to calculate survival outcomes. RESULTS: The 2-year event-free survival and overall survival rates were 66% and 56%, respectively (71.4% and 60.0% in AML patients vs. 64.3% and 52.4% in ALL patients, respectively). Treatment related mortality rate were 25%. Acute and chronic graft-versus-host disease was a major complication; other complications included endocrine dysfunction and pulmonary complications. Common complications from TBI were nausea (89%) and cataracts (7.1%). CONCLUSION: The efficacy and toxicity data in this study of TBI-based conditioning to pediatric acute leukemia patients were comparable with previous studies. However, clinicians need to focus on the acute and chronic complications related to allo-SCT.
