Research Progress on Effect of Bone Marrow Microenvironment Regulated by IL-6/IL-6R/JAK2/STAT3 Pathway on Biological Behavior of Multiple Myeloma

VernacularTitle:IL-6/IL-6R/JAK2/STAT3通路调控骨髓微环境对多发性骨髓瘤生物学行为影响的研究进展
Author: Yu-Shi SHI ¹ ; Jia-Wei XU ; Qing-Qing LIU ; Yi-Qiang LI ; Wei-Min CHENG
Author Information

1. 广西中医药大学第一临床医学院,广西南宁 530200
Keywords: multiple myeloma; bone marrow microenvironment; interleukin-6/interleukin-6 receptor; Janus kinase 2; signal transducer and activator of transcription 3
From: Journal of Experimental Hematology 2024;32(1):318-321
CountryChina
Language:Chinese
Abstract: Multiple myeloma(MM)is a malignant disease with abnormal proliferation of clonal plasma cells.The development of the disease shows a vast heterogeneity,which is closely related to the interaction between MM cells and bone marrow microenvironment(BMM).The interleukin-6(IL-6)/interleukin-6 receptor(IL-6R)/Janus kinase 2(JAK2)/signal transducer and activator of transcription 3(STAT3)pathway can regulate the transcription of related soluble factors in BMM,promote the proliferation,anti-apoptosis,drug resistance and guide related bone destruction of MM cells.This article reviews the research progress on the effect of BMM regulated by IL-6/IL-6R/JAK2/STAT3 pathway on the biological behavior of MM,in order to provide new research ideas for targeted therapy and precise therapy of MM.