Research Progress on the Roles of Rapamycin for the Prophylaxis and Treatment of Graft-Versus-Host Disease

VernacularTitle:雷帕霉素在移植物抗宿主病防治中作用的研究进展
Author: Dan WANG ¹ ; Jing WEI ; Yi-Mei FENG ; Xi ZHANG
Author Information

1. 川北医学院附属医院血液科,四川南充 637000;陆军军医大学第二附属医院(新桥医院)血液病医学中心,重庆 400037
Keywords: rapamycin; graft-versus-host disease; adverse events; lymphocyte subsets
From: Journal of Experimental Hematology 2024;32(1):302-307
CountryChina
Language:Chinese
Abstract: Graft-versus-host disease(GVHD)reduces the clinical effect and life quality of patients after allogeneic hematopoietic stem cell transplantation(HSCT).Especially for steroid-resistant GVHD,it becomes essential to explore new prevention and treatment strategies.Rapamycin has shown certain clinical advantages in the prevention and treatment of acute and chronic GVHD by inhibiting the mTOR signal pathway.Furthermore,rapamycin exhibits the ability to regulate cell subsets,including T cells,B cell,dendritic cells and myeloid-derived suppressor cells,which elucidates the mechanism on effective preventing and treating GVHD.This article reviewed the roles of mTOR inhibitor-rapamycin on GVHD,and discussed how to optimize the usage of rapamycin.