Research Progress of Pyroptosis in Leukemia:from Mechanism to Treatment
10.19746/j.cnki.issn1009-2137.2024.01.046
- VernacularTitle:细胞焦亡在白血病中的研究进展:从机制到治疗
- Author:
Ling-Yan ZHOU
1
;
Xiao-Cheng YIN
Author Information
1. 南华大学衡阳医学院附属第一医院儿科,湖南衡阳 421600
- Keywords:
pyroptosis;
leukemia;
gasdermin protein
- From:
Journal of Experimental Hematology
2024;32(1):287-291
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a programmed death mediated by activated caspase and Gasdermin family proteins,characterized by cell swelling,cytosolysis and release of inflammatory factors.Leukemia is a malignant disease characterized by abnormal differentiation and proliferation of hematopoietic stem cells,thus seriously threating human health.In recent years,it has been found that the transformation,proliferation,metastasis and treatment response of leukemia cells are closely related to pyrodeath.Pyroptosis provides a new perspective for the study of leukemia.This paper reviews the types and molecular mechanisms of pyroptosis,the role of pyroptosis in the occurrence and development of leukemia and the treatment of leukemia,so as to provide some references for further study of the relationship between pyroptosis and leukemia,in order to provide a new strategy for the treatment of leukemia.
