Research progress on the role of mitochondrial damage in inflammatory bowel disease

VernacularTitle:线粒体损伤在炎症性肠病中的研究进展
Author: Xiaoting WU ¹ ; Ang XUAN ; Juan SHEN
Author Information

1. 广东药科大学,广东省药物生物活性物质重点实验室,广州 510006
Keywords: inflammatory bowel disease; mitochondria; impairment; dysfunction
From: Chinese Journal of Comparative Medicine 2024;34(9):165-171
CountryChina
Language:Chinese
Abstract: Inflammatory bowel disease(IBD)is a chronic and relapsing inflammatory disorder of the gastrointestinal tract that poses a significant threat to human health.The pathogenesis of IBD remains unclear and is believed to involve various factors,including genetics,immune dysregulation,and environmental triggers.Recent evidence has highlighted the role of mitochondrial damage and dysfunction in the development of IBD.This article provides a comprehensive review and overview of studies related to the role of mitochondrial damage in IBD,focusing on the effects of mitochondrial oxidative stress damage,autophagy dysfunction,kinetic disturbances,and respiratory defects.The aim is to identify potential therapeutic targets and provide new insights for the scientific prevention and treatment of IBD.