Progress in the study of mechanism of acupuncture in regulating ferroptosis after ischemic stroke

VernacularTitle:针刺调控缺血性卒中后铁死亡的作用机制研究进展
Author: Jing XUE ¹ ; Ying GAO ; Shu WANG
Author Information

1. 天津中医药大学第一附属医院,天津 300072;国家中医针灸临床医学研究中心,天津 300381
Keywords: acupuncture; ischemic stroke; ferroptosis; iron; lipid peroxidation
From: Chinese Journal of Comparative Medicine 2024;34(4):129-138
CountryChina
Language:Chinese
Abstract: Ischemic stroke(IS)presents a complex pathogenesis that poses numerous challenges in its treatment and rehabilitation.Acupuncture,a traditional Chinese medicine treatment,has garnered widespread attention for its effectiveness in treating IS,particularly its regulation of ferroptosis.Ferroptosis is a type of cell death dependent on iron and lipid peroxidation and is closely linked to neurological impairment following IS.This article reviews the primary mechanisms of ferroptosis post-IS,emphasizing the interconnections among iron metabolism,lipid peroxidation,mitochondrial damage,and ferroptosis.It further explores the mechanisms behind the ability of acupuncture to regulate ferroptosis after IS,including its roles in enhancing mitochondrial function,modulating iron metabolism,alleviating oxidative stress,suppressing inflammatory responses,and influencing various ferroptosis signaling pathways.This paper aims to provide a review of the scientific evidence and theoretical support for comprehensive therapeutic strategies for IS.