Progress of research into pyroptosis in renal ischemia-reperfusion injury
10.3969/j.issn.1671-7856.2024.03.021
- VernacularTitle:细胞焦亡在肾缺血再灌注损伤中的研究进展
- Author:
Haojie SUN
1
;
Junlei ZHU
;
Wei LI
;
Suogang WANG
Author Information
1. 河南中医药大学第一附属医院泌尿外科一区,郑州 450003;河南中医药大学第一临床医学院,郑州 450003
- Keywords:
kidney transplantation;
ischemia-reperfusion injury;
pyroptosis;
inhibitors;
intervention means
- From:
Chinese Journal of Comparative Medicine
2024;34(3):172-178
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a programmed cell death mediated by cysteine proteases and is characterized by mitochondrial participation,inflammasome assembly,plasma membrane perforation,and inflammatory release.As an important mechanism mediating the body's inflammatory responses,pyroptosis plays a key role in renal ischemia-reperfusion injury(RIRI).This article reviews the molecular mechanisms of pyroptosis,pyroptotic mechanisms in RIRI,and the progress of research into therapeutic drugs in recent years,with the aim of providing a theoretical reference for the development of early treatments for RIRI.
