Experimental study on the health hazards of respiratory exposure to brake pad particles and their main component antimony sulfide in mice
10.3969/j.issn.1671-7856.2024.03.002
- VernacularTitle:刹车片颗粒及其主要成分硫化锑呼吸暴露对小鼠健康危害研究
- Author:
Yanhong LI
1
;
Jinghui XIU
;
Li ZHOU
;
Jianguo GUO
Author Information
1. 中国医学科学院医学实验动物研究所,北京协和医学院比较医学中心,国家卫生健康委员会人类疾病比较医学重点实验室,国家中医药管理局人类动物模型三级实验室,北京 100021
- Keywords:
brake pad particles;
antimony sulfide;
PM2.5;
inflammation;
immune response
- From:
Chinese Journal of Comparative Medicine
2024;34(3):10-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the potential harmful effects of brake-pad sourced particles.Methods Grind the brake pad particles or antimony sulfide particles.Mice were exposed brake pad or antimony sulfide particles by tracheal perfusion for 1 month.We observed pathological changes to the lungs,heart,and liver,and analyzed changes in peripheral blood macrophages and regulatory T cells(Tregs)via flow cytometry.Results After exposure,the deposition of foreign substances in the alveolar wall of mice was seen,with the obvious infiltration of inflammatory cells around blood vessels,which worsened with increasing particle concentration.Pathological changes,such as vascular inflammation and microthrombosis in the heart and hepatocyte swelling in the liver,were observed.Treg cells in peripheral blood decreased and macrophages increased in the antimony sulfide group and low-dose brake pad particles group,while the proportion of M2-type macrophages decreased,in the antimony sulfide group and low-dose brake pad particle group.Conclusions Exposure to brake pad particles and their component antimony sulfide has varying degrees of toxic effects on the lung,heart,and liver of mice and has an impact on the immune system,indicating the potential health hazards of brake-pad-derived air pollution.
