Monoamine oxidase A:new tumor immunity target of neural origin
10.3969/j.issn.1005-4847.2024.10.011
- VernacularTitle:单胺氧化酶A:神经起源的肿瘤免疫新靶点
- Author:
Yifan MA
1
;
Hui LI
;
Hanmu CHEN
;
Changhong SHI
Author Information
1. 甘肃中医药大学第一临床医学院,兰州 730030;空军军医大学实验动物中心,西安 710032
- Keywords:
monoamine oxidase A;
tumor immunity;
CD8+T cells;
tumor-associated macrophages
- From:
Acta Laboratorium Animalis Scientia Sinica
2024;32(10):1332-1338
- CountryChina
- Language:Chinese
-
Abstract:
Monoamine oxidase A(MAOA)is a membrane-bound mitochondrial enzyme that exists in almost all vertebrate tissues,where it catalyzes the degradation of biogenic and dietary-derived monoamines.MAOA has the function of regulating neurotransmitter metabolism and is associated with anti-tumor immune responses.Most previous studies have focused on the role of MAOA in tumor cells,while more recent findings suggest that MAOA plays an equally significant role in tumor-associated immune cells.In this review,we summarize the regulatory effect of MAOA on the inhibitory tumor microenvironment.The suppressing function of MAOA on various types of tumor-associated immune cells(e.g.,CD8+T cells and tumor-associated macrophages)by its direct effect on monoamines and their metabolic characteristics are discussed.We propose that developing novel MAOA-inhibitor drugs and exploring multidrug-combination strategies may enhance the efficacy of immune therapy for tumors.In conclusion,MAOA may act as a novel target in tumor immunity and influence the effect of tumor immunotherapy.
