The Regulatory Role of m6A Modification in Viral Infection of Host Cells
10.13865/j.cnki.cjbmb.2024.08.1068
- VernacularTitle:m6 A修饰在病毒感染宿主细胞中的调节作用
- Author:
Yue-Ping XIA
1
;
Fen HUANG
Author Information
1. 昆明理工大学生命科学与技术学院&医学院,昆明 650500
- Keywords:
N6-methyladenosine(m6A);
m6A methyltransferase;
m6A demethylase;
m6A reading pro-teins;
virus
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(10):1362-1373
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenosine(m6A)is a methylation modification on the 6th nitrogen atom of the RNA molecule adenine,and is the most common post-transcriptional modification in messenger RNA(mRNA)and non-coding RNA(ncRNA).m6A modification plays a crucial role in all stage of RNA cy-cle,including RNA stabilization,splicing,nuclear export,folding,translation and degradation.m6A modification requires the participation of methyltransferase(writers),demethylase(erasers)and m6 A readers.The important roles of m6A modification involved in virus-host interactions have been largely ex-plored based on the rapid development of high-throughput RNA sequencing technology.Studies have shown that m6A modification participates in a variety of viral RNAs,and is associated with viral en-trance,replication and progeny virion release.Viruses can also alter host transcriptome by m6A modifica-tion to impact viral infectivity or host resistance.This review explored the role of m6A modification in re-spiratory virus,retrovirus and herpes virus,etc.infected cells,and the regulatory effects of m6A modifi-cations on viral replication and host immune response.It will help to further clarify the mechanisms of vi-rus-host interactions and benefit the development of antiviral drugs.
