Roles of Pyroptosis in Oral Diseases
10.13865/j.cnki.cjbmb.2024.05.1055
- VernacularTitle:细胞焦亡及其在口腔疾病中的作用
- Author:
Zheng-Sen WANG
1
;
Yu XUE
;
Yi-Xuan CHEN
Author Information
1. 闽南师范大学菌物产业福建省高校工程研究中心,福建漳州 363000
- Keywords:
pyroptosis;
inflammasome;
inflammation;
oral disease
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(9):1230-1239
- CountryChina
- Language:Chinese
-
Abstract:
Oral diseases are usually caused by external physical and chemical factors,the invasion of pathogens,dento-maxillofacial deformities and systemic diseases.Oral infections and orofacial pain triggered by oral diseases seriously reduce the quality of life.Pyroptosis is a kind of programmed cell death,which is characterized by swelling of the cell until the cell membrane ruptures,releasing the cell contents and activating a strong inflammatory response.Previous studies have shown that pyroptosis is widely involved in the occurrence and development of oral diseases.In this review,four types of cellular pyroptosis pathways are described in detail,including the canonical pathway,non-canonical pathway,caspase-3/8 mediated pathway and caspase independent pathway.Different pyroptosis pathways form complex signal networks,which regulate the functions of periodontal membrane cells,gingival fibroblasts,macrophages and other cells in the oral cavity,thus affecting the occurrence and development of oral diseases.This review summarizes the latest research about the pathways of pyroptosis and its roles in oral diseases,aiming to provide a theoretical basis and direction for searching effective methods to treat and prevent oral diseases.
