Regulation of Autophage and Ferroptosis by m6A to Affect the Growth of Tumor Cell

VernacularTitle:m6A调控细胞自噬和铁死亡途径影响肿瘤细胞生长
Author: Ming-Yang LI ¹ ; Shuang TAO ; Guo-Hui LI
Author Information

1. 江苏大学,生命科学学院,生物科学系,江苏镇江 212013
Keywords: N6-methyladenosine(m6A); autophagy; ferroptosis; tumor
From: Chinese Journal of Biochemistry and Molecular Biology 2024;40(9):1222-1229
CountryChina
Language:Chinese
Abstract: N6-methyladenosine(m6A)modification involves the methylation of the sixth nitrogen atom on the base A of RNA molecules.It is the most common and abundant RNA epigenetic modification in eukaryotic organism.It could not only directly affect the transcriptional level of intracellular genome,but also regulate the expression level of oncogenes,tumor suppressor genes and some ncRNA genes.Additionally,some autophagy-related genes and ferroptosis metabolism pathway-related genes were also reported to be regulated by m6A.The abnormal regulation and dysfunction of target genes by m6A usually promote or inhibit the growth of tumor cells.Therefore,the regulation of cellular autophagy and ferroptosis by m6A to affect the growth of tumor was summarized in the study.It will be useful to demonstrate the mechanism of tumorigenesis and provide scientific basis for the development of a novel target on the treatment of tumor.