The Applications of CRISPR Screening in Aging Research
10.13865/j.cnki.cjbmb.2024.07.1197
- VernacularTitle:CRISPR筛选在衰老研究中的应用
- Author:
Jia-Xin XU
1
;
Yao-Bin JING
;
Jing QU
;
Guang-Hui LIU
Author Information
1. 海南医科大学(海南省医学科学院)衰老与肿瘤国际研究中心,海口 571199
- Keywords:
Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR);
genetic screening;
aging
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(9):1186-1196
- CountryChina
- Language:Chinese
-
Abstract:
The advancement of Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR)gene editing technology has revolutionized the comprehension of human genome,propelling molecular and cellular biology research into unexplored realms and accelerating progress in life sciences and medicine.CRISPR-based gene screening,recognized for its efficiency and practicality,is widely utilized across diverse biological fields.Aging is a multifaceted process governed by a myriad of genetic and epigenetic factors.Unraveling the genes regulating aging holds promise for understanding this intricate phenomenon and devising strategies for its assessment and intervention.This review provides a comprehensive overview of the progress in CRISPR screening and its applications in aging research,while also offering insights into future directions.CRISPR-based genetic-manipulation tools are positioned as indispensable instruments for mitigating aging and managing age-related diseases.
