Therapeutic Effects of Black Phosphorus Nanosheets in Parkinson's Disease
10.13865/j.cnki.cjbmb.2024.06.1487
- VernacularTitle:黑磷纳米片在帕金森病中的治疗作用
- Author:
Jia-Li YUAN
1
;
Chun-Lin ZHANG
;
Li LEI
Author Information
1. 基础医学院生物教研室,基础医学院分子医学工程中心,贵州医科大学,贵阳 561113
- Keywords:
Parkinson's disease(PD);
black phosphorus nanosheets;
blood-brain barrier;
neuropro-tection
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(8):1112-1118
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease(PD)is a heritable degenerative disease of the central nervous system.Symptoms such as dyskinesia are caused by dysregulation of mesencephalic dopamine metabolism.Cur-rently,although the drugs used for the treatment of Parkinson's disease have been developed to target the pathogenesis of the disease,there are still some deficiencies in blood-brain barrier permeability that lead to the poor therapeutic effects of these drugs.And nanomaterials offer a solution to Parkinson's disease treatment by targeting drugs to specific regions,solving the deficiency in site-specific delivery.Nanoma-terials have unique physicochemical properties and can cross the blood-brain barrier by different mecha-nisms.New research identifies therapeutic drugs carrying nanocarriers and suitable ligands that help im-prove the distribution of hydrophilic drugs in the brain for site-specific drug delivery.Black phosphorus is a novel nanomaterial that has attracted much attention in the last five years and has been widely used in biomedical research due to its unique structure-endowed properties,including superior photothermal/pho-todynamic properties,reducing properties,high drug-carrying capacity,and good biocompatibility.In this review,we try to present the mechanism of Parkinson's disease and the applicability of black phos-phorus nanosheets in its treatment.
