Regulation of Tumor Immunity by Mtp53 and Its Application in Immunotherapy
10.13865/j.cnki.cjbmb.2024.06.1453
- VernacularTitle:Mtp53对肿瘤免疫的调控及其在免疫治疗中的应用
- Author:
Qi-You CAO
1
;
Cui-Xia DI
;
Jun-Ling WANG
Author Information
1. 兰州大学公共卫生学院卫生毒理学研究系,兰州 730000;中国科学院近代物理研究所生物医学中心医学物理室,兰州 730000
- Keywords:
p53;
p53 mutant/mtp53;
tumor immunity;
immunotherapy
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(8):1031-1042
- CountryChina
- Language:Chinese
-
Abstract:
p53 is an important tumor suppressor in the body,but research has found that p53 is one of the most frequent alterations in nearly half of human cancers.Mutant p53(mtp53)not only promotes tumor development but also serves as a pivotal factor in tumor immunity.Research has demonstrated that mtp53 participates in many aspects of tumor immune response through multiple mechanisms.We firstly describe the structure and function of mtp53,then the molecular mechanisms of mtp53 in tumor immuni-ty,including four aspects of promoting tumor immune escape,facilitating oxidative stress,regulating tumor-associated inflammatory signaling networks and tumor-infiltrating immune cell recruitment and dif-ferentiation.Finally,we summarize the effects of mtp53 on the immune micro-environment of lung canc-er,triple-negative breast cancer and colorectal cancer as well as the advances in the application of mtp53 in the treatment of cancers with PD-1/PD-L1 inhibitors,which may provide suitable directions and op-tions for the immunotherapy of mtp53-expressing cancers.
