Mechanisms of Microglia Polarization-mediated Neuroinflammation in Vascular Dementia
10.13865/j.cnki.cjbmb.2024.03.1451
- VernacularTitle:小胶质细胞极化介导的神经炎症在血管性痴呆中的作用机制
- Author:
Lu-Yao MA
1
;
Yan-Jie LI
;
He-Wei QIN
Author Information
1. 河南中医药大学康复医学院,郑州 450046
- Keywords:
microglia;
polarization;
neuroinflammation;
vascular dementia(VD);
signaling pathways
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(7):907-913
- CountryChina
- Language:Chinese
-
Abstract:
Vascular dementia is a cognitive impairment caused by cerebrovascular disease.Its pathogen-esis is derived from a series of pathological processes such as low cerebral blood perfusion caused by cere-brovascular damage.Microglia is an important part of the human innate immune system.Under the stimu-lation of different microenvironmental signals,microglia can differentiate into Ml type with pro-inflamma-tory effects and M2 type with anti-inflammatory effects,and produce a variety of cytokines with neurotoxic or neuroprotective effects.In recent years,regulating the polarization of microglia and reducing excessive inflammatory response have become important strategies for the treatment of neurodegenerative diseases.By introducing the main signaling pathways related to microglia polarization and the role of microglia po-larization-mediated neuroinflammation in vascular dementia,this paper clarified the important role of mi-croglia polarization balance in the treatment of vascular dementia and provided new ideas for related clini-cal research.
