RNA 8-hydroxyguanosine Modification:New Insights into an Old Modification
10.13865/j.cnki.cjbmb.2024.05.1021
- VernacularTitle:RNA 8-羟基鸟嘌呤修饰:旧貌新颜
- Author:
Hu-Jie LI
1
;
Zheng-Yue CAO
;
Xiao-Fei ZHENG
Author Information
1. 河北大学化学与材料科学学院药物化学与分子诊断教育部重点实验室,河北省化学生物学重点实验室,河北保定 071002;军事科学院军事医学研究院辐射医学研究所实验血液学与生物化学研究室,放射生物学北京市重点实验室,北京 100850
- Keywords:
RNA oxidation;
8-hydroxyguanosine(8-OHG);
oxidative stress;
repair;
disease
- From:
Chinese Journal of Biochemistry and Molecular Biology
2024;40(6):731-739
- CountryChina
- Language:Chinese
-
Abstract:
Various types of RNA within cells play crucial roles in regulating cellular biological processes.RNA modifications are chemical modifications on substrate RNA with chemical groups.8-hydrox-yguanosine modification of RNA can impact the stability,structure and function of RNA.This modifica-tion enhances the diversity of RNA functions and roles.During oxidative stress,8-hydroxyguanine is a common and signature form of RNA chemical oxidative modification in cells.Both the structure and func-tion of RNA may be affected by 8-hydroxyguanine modification.The 8-hydroxyguanine modification of RNA has been demonstrated to impact both the structure and function of RNA through the induction of RNA strand breaks and base shedding.Research suggests that the presence of 8-hydroxyguanine modifi-cation in RNA may serve as a potential biomarker for disease progression.As interests in RNA modifica-tions grow,the 8-hydroxyguanine modification of RNA has garnered increasing attention.This article mainly reviews the mechanisms involved in the generation of 8-hydroxyguanine modification in RNA,its biological implications,and the proteins involved in regulating and repairing this modification,the detec-tion technology for 8-hydroxyguanine modified RNA,and the relationship between 8-hydroxyguanine mod-ification of RNA and various diseases,including neuropathic diseases and cancer.The primary objective is to offer a deeper understanding of the biological significance of RNA modification and the potential in-volvement of 8-hydroxyguanine modified RNA in disease pathogenesis.
