Research progress on ketamine for the treatment of substance use disorders
10.3969/j.issn.1002-0152.2024.10.011
- VernacularTitle:氯胺酮治疗物质使用障碍研究进展
- Author:
Tinghan FU
1
;
Huanzhong LIU
;
Kai ZHANG
Author Information
1. 安徽医科大学附属巢湖医院精神科(合肥 238000);安徽医科大学精神卫生与心理科学学院
- Keywords:
Substance use disorder;
Ketamine;
Alcohol use disorders;
Cocaine use disorder;
Opioid use disor-ders;
Neuroplasticity;
Brain-derived neurotrophic factor;
Adverse reaction
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(10):627-631
- CountryChina
- Language:Chinese
-
Abstract:
Substance use disorder is a complex health condition characterized by excessive dependence and abuse of psychoactive substances.Current treatments are few and generally ineffective,and new treatment methods are urgently needed.In recent years,ketamine has been found to be effective in the treatment of substance use disorders in controlling relapse rates and reducing withdrawal reactions in clinical studies.Basic research has shown that ketamine has a therapeutic effect by altering neuroplasticity and modulating neurofunctional networks.However,the use of ketamine may lead to side effects such as increased blood pressure and psychiatric symptoms,and potential addiction.But current clinical studies are optimistic about its safety.As a fast-acting drug with a novel mechanism of action,ketamine needs to be studied in depth to explore its benefits and risks,thereby providing a safe and effective new method for the treatment of substance use disorders.
