Research progress of nanomaterials in nose-to-brain delivery for glioblastoma treatment
10.3969/j.issn.1002-0152.2024.03.013
- VernacularTitle:纳米材料在鼻脑通路治疗胶质母细胞瘤研究进展
- Author:
Zibin SONG
1
;
Jiajie YUAN
;
Yunjiao CHEN
;
Jianfeng LI
;
Jun PAN
Author Information
1. 南方医科大学南方医院神经外科,脑病研究院(广州 510515)
- Keywords:
Glioblastoma;
Nose-to-brain pathway;
Polymers;
Liposomes;
Inorganic metal nanomaterials
- From:
Chinese Journal of Nervous and Mental Diseases
2024;50(3):183-188
- CountryChina
- Language:Chinese
-
Abstract:
Glioblastoma(GBM)stands as one of the most aggressive brain tumors,and its pharmacological therapy is severely limited due to the presence of the blood-brain barrier(BBB).Nose-to-brain drug delivery has emerged as a promising approach for directly targeting the central nervous system(CNS)by circumventing the BBB.The nasal cavity is anatomically partitioned into the vestibular,olfactory,and respiratory regions.Nanomedicines can efficiently transport to the CNS through the olfactory pathway of the olfactory region and the trigeminal nerve pathway of the respiratory region.In recent years,nanodelivery platforms in nasal administration for treating GBM have garnered widespread attention,primarily involving polymers,liposomes,inorganic metal nanoparticles,and so on.The advancement of these technologies presents novel avenues and selections for overcoming the BBB,enhancing drug delivery efficacy,and improving the prognosis of GBM patients.
