Cavitation as a risk factor for treatment failure in patients with Mycobacterium avium infection
10.3969/j.issn.1002-2694.2024.00.074
- VernacularTitle:空洞是鸟分枝杆菌感染患者治疗失败的危险因素
- Author:
Xin ZOU
1
;
Meng-Xing LUO
;
Lu-Lu CHEN
;
Yu-Yan XU
;
Zhong-Hua LIU
Author Information
1. 贵州医科大学公共卫生与健康学院,环境污染与疾病监控教育部重点实验室,贵阳 561113;同济大学医学院附属上海市肺科医院,结核重点实验室,上海 200433
- Keywords:
Mycobacterium avium;
treatment failure;
cavity
- From:
Chinese Journal of Zoonoses
2024;40(5):483-488
- CountryChina
- Language:Chinese
-
Abstract:
This study investigated the risk factors for treatment failure in patients with a single infection of Mycobacterium avium.Patients with Mycobacterium avium infection meeting the guidelines for diagnosis and treatment of non-tuberculous mycobacteriosis between January 2016 and December 2020 at Shanghai Pulmonary Hospital were included.A logistic regression model was used to analyze the risk factors for treatment failure.A total of 26(49％)of 53 patients with Mycobacterium avium infection included in the study had treatment failure.A higher proportion of patients with fever,anemia,and lung cavitation in the treatment failure group had significantly higher neutrophils and direct bilirubin,and significantly lower prealbumin.Multi-factorial logistic regression demonstrated that cavitation was an independent risk factor for treatment failure in patients with Mycobacterium avium infection,and Kaplan-Meier analysis indicated significantly lower cumulative 12-month cure rates in pa-tients with cavitation.Patients with Mycobacterium avium infection had a higher rate of treatment failure,and cavitation was found to be a risk factor for treatment failure.Our findings suggest that clinicians should pay attention to the monitoring and treatment of patients with Mycobacterium avium pulmonary cavities to improve the cure rate among patients.
