Chain of transmission and gene sequence analysis of SARS-CoV-2 Omicron BA.2.3.7 infection caused by a cold chain product
10.3969/j.issn.1002-2694.2024.00.047
- VernacularTitle:1起由冷链产品引起的新型冠状病毒Omicron BA.2.3.7感染的传播链和基因序列分析
- Author:
Xin-Xin YANG
1
;
Zhi-Wei CHEN
;
Min-Hong CHEN
;
Hai-Mei JIA
;
Xiao-Yang ZHANG
Author Information
1. 福建医科大学附属福州市疾病预防控制中心,福州 350005;福建医科大学公共卫生学院,福州 350122
- Keywords:
SARS-CoV-2;
object-to-human transmission;
cold chain;
whole genome sequencing;
Omicron variant
- From:
Chinese Journal of Zoonoses
2024;40(4):384-390
- CountryChina
- Language:Chinese
-
Abstract:
The aim of this study was to trace to origin of SARS-CoV-2 originating from imported cold-chain products re-sponsible for an outbreak that occurred on September 6-9,2022 in Mawei District,Fuzhou City,Fujian Province,China.Sam-ples from all positively infected persons and one positive sample from a swab of a cold-chain product during the outbreak were collected for gene sequencing.Epidemiological investigations were conducted on all positively infected persons to analyze the chain of transmission of the virus.Nucleic acids were detected by real-time fluorescence quantitative PCR,and the outbreak was characterized by a total of eight positive infections,which were asymptomatic.Whole-genome sequencing of three infected per-sons and one cold-chain product sample identified 75 nucleotides and 55 amino acid mutation sites of the BA.2.3.7 variant,with four highly homologous whole-genome sequences.These results confirmed that the outbreak was caused by exposure to impor-ted cold-chain products carrying the SARS-CoV-2 Omicron BA.2.3.7 strain.
