Research on suspected cases of Lyme disease in Ji'an City,Jiangxi Province
10.3969/j.issn.1002-2694.2024.00.058
- VernacularTitle:江西省吉安市莱姆病疑似病例调查研究
- Author:
Zhi-Yun LIU
1
;
Yu ZENG
;
Li-Ke DUAN
;
Xue-Xia HOU
;
Lin ZHANG
;
Li-Juan HE
;
Qin HAO
Author Information
1. 吉安市中心人民医院,吉安 343000
- Keywords:
Lyme disease;
Borrelia yangtzensis;
nucleic acid test;
antibody test
- From:
Chinese Journal of Zoonoses
2024;40(4):340-345
- CountryChina
- Language:Chinese
-
Abstract:
Confirmed cases of Lyme disease(LD)in Ji'an City,Jiangxi Province and the clinical manifestations and region-al distribution were assessed to provide a basis for timely diagnosis and treatment.In total,133 serum samples were collected from patients with suspected LD in Ji'an Central People's Hospital from December 2021 to August 2022.Serum antibodies a-gainst Borrelia burgdorferi were detected with a two-step testing process.In addition,a specific gene of B.burgdorferi in samples was identified by nested PCR.Sequencing analysis was conducted to confirm the positive samples.Overall,25(18.80％)serum samples were positive for B.burgdorferi nucleic acid and antibodies,which included 20(15.04％)positive for antibodies and 6(4.51％)positive for nucleic acids.The sequences of the 5S-23S rRNA gene spacer of 6 samples were con-sistent with the corresponding sequences of Borrelia yangtzensis and one of the six samples was also positive for antibodies.The 25 positive samples were collected from 9 counties in Ji'an City,with the majority in Jizhou District(44％).All positive patients may experience symptoms related to LD,including joint disorders,neurological disorders,infectious fever,der-matitis,and/or chest pain.The most common symptom was joint disorders(72％).Six cases positive for B.yangtzensis nucleic acids were mainly collected in the Jizhou District,of which four had joint lesions and two had infectious fever.This study confirms the existence of LD in Jiangxi Province,which may be the first confirmation of human infection with B.yan-gtzensis in southern China.Hence,doctors in this region should consider the possibility of LD for cases presenting with related symptoms.Although LD may occur in this region,further investigations and monitoring are warranted.
