The potential mechanism of intestinal microbiota affecting amyloid deposition in cerebral amyloid angiopathy
10.3969/j.issn.1672-5921.2024.09.010
- VernacularTitle:肠道菌群影响脑淀粉样血管病中淀粉样蛋白沉积的潜在机制探讨
- Author:
Dan ZHANG
1
;
Xiaodong YE
;
Shanshan HUANG
;
Suiqiang ZHU
Author Information
1. 430030 武汉,华中科技大学同济医学院附属同济医院神经科
- Keywords:
Cerebral amyloid angiopathy;
Intestinal microbiota;
Amyloid-β;
Review
- From:
Chinese Journal of Cerebrovascular Diseases
2024;21(9):643-649
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral amyloid angiopathy(CAA)is one of the cerebral small vessel diseases in which amyloid-β is deposited in the cortical,subcortical and leptomeningal arterioles.The disease is commonly encountered in the elderly,characterized by recurrent lobar hemorrhage and cognitive dysfunction.In recent years,the diversity of intestinal microbiota and its products have been reported to be involved in the pathogenic process of central nervous system diseases through various pathways such as neuroinflammation and blood brain barrier leakage.However,the underlying mechanism of intestinal microbiota in CAA is not clear.It has been reported that intestinal microbiota disorder can induce intracranial Aβ production and aggregation,blood-brain barrier leakage,and Aβ transport receptor imbalance,and then damage in blood vessels,accompanied by neuroinflammatory mechanisms.The authors reviewed the potential mechanism of intestinal microbiota involved in amyloid deposition to provide a theoretical reference for the exploration of potential clinical therapeutic targets for CAA.
