Research progress on regulation of interferon production and inflammatory response by coronavirus
10.3969/j.issn.1000-484X.2024.12.035
- VernacularTitle:冠状病毒调节干扰素应答和炎症反应的研究进展
- Author:
Sha XIE
1
;
Guanmin ZHENG
;
Yangang SUN
Author Information
1. 河南中医药大学医学院,郑州 450046
- Keywords:
Coronavirus;
Innate immune;
Interferon;
Inflammation
- From:
Chinese Journal of Immunology
2024;40(12):2661-2665,2675
- CountryChina
- Language:Chinese
-
Abstract:
Coronaviruses are important pathogens that cause respiratory diseases in humans,such as common cold or severe respiratory symptoms.After coronavirus infects host cells,innate immune system recognizes invading virus through sensing its patho-gen-associated molecular patterns with various pattern recognition receptors,and antiviral immune response is activated.Increased production of IFN and pro-inflammatory will inhibit proliferation of coronavirus.In addition,coronavirus has ability to escape innate immune response,which is conducive to proliferation of virus.In this review,we describe relevant studies on regulation of IFN response and inflammatory response of coronaviruses,to provide new ideas for prevention and treatment of coronavirus infection.
