Research progress of HHLA2
10.3969/j.issn.1000-484X.2024.11.030
- VernacularTitle:HHLA2分子研究进展
- Author:
Yuanbo WANG
1
;
Haoyu SUN
Author Information
1. 中国科学技术大学免疫学研究所,合肥 230027
- Keywords:
HHLA2;
Cancer;
KIR3DL3;
Immunoregulation
- From:
Chinese Journal of Immunology
2024;40(11):2416-2420,2426
- CountryChina
- Language:Chinese
-
Abstract:
Human endogenous retrovirus-H long terminal repeat associated protein 2(HHLA2)is mainly expressed on antigen-presenting cells(APC)and tumor cells,and highly expressed in cancer tissue and its expression is correlated with prognosis,which suggests that HHLA2 may be a potential biomarker for predicting anti-tumor treatment.At the same time,HHLA2/KIR3DL3 is a newly discovered popular immunosuppressive pathway,which plays an important role in regulation of adaptive immune response.This review summarizes discovery and evolution of HHLA2,association between expression of HHLA2 and prognosis,and regulatory role of HHLA2 in immune system.
