Predictive value of Th immune response indicators for asthma control in children with cough variant asthma and its relationship with recurrence risk
10.3969/j.issn.1000-484X.2024.11.021
- VernacularTitle:Th免疫应答指标对咳嗽变异性哮喘患儿哮喘控制情况的预测价值及其与复发风险的关系
- Author:
Lijuan LIU
1
;
Dan SU
;
Wanhui LI
;
Zhanru YIN
Author Information
1. 衡水市人民医院,衡水 053000
- Keywords:
Cough variant asthma;
Th1/Th2 cytokines;
Asthma control;
Prediction;
Relapse
- From:
Chinese Journal of Immunology
2024;40(11):2368-2372
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the predictive value of helper T cell(Th)immune response indicators for asthma control in children with cough variant asthma(CVA)and its relationship with the risk of recurrence.Methods:A total of 112 children with CVA in Hengshui City People's Hospital from August 2020 to August 2021 were selected,all received conventional western medicine treat-ment,and were divided into well-controlled group(n=85)and poorly-controlled group(n=27)according to their asthma control status after 4 weeks of treatment.compare the general data,pulmonary function indexes before treatment[forced expiratory volume in 1 se-cond(FEV1),FEV1/forced vital capacity(FVC)],Th immune response indexes(Th1/Th2,IL-2,IFN-γ,IL-4,IL-10)levels,ana-lyze the correlation between Th immune response indicators and pulmonary function indicators,and predict the value of asthma control in children with CVA.After 6 months of follow-up,the recurrence situation in the well-controlled group was counted,the Th immune response indexes before treatment were compared between the children with recurrence and those without recurrence,and the relation-ship between Th immune response indexes and recurrence were analyzed.Results:Before treatment,the levels of FEV1,FEV1/FVC,Th1/Th2,IL-2 and IFN-γ in the poor control group were lower than those in the well-controlled group,and the levels of IL-4 and IL-10 were higher than those in the well-controlled group(P<0.05).Th1/Th2,IL-2,IFN-γ levels were positively correlated with FEV1,FEV1/FVC before treatment in children with CVA,and IL-4,IL-10 levels were negatively correlated with FEV1,FEV1/FVC(P<0.05);the areas under the curve(AUC)of Th1/Th2,IL-2,IFN-γ,IL-4 and IL-10 levels before treatment for predicting poor asthma control in children with CVA were all>0.7,and the combined predicted AUC(0.933)was the largest;before treatment,the levels of Th1/Th2,IL-2 and IFN-γ in the relapsed children in the group were lower than those of the non-relapsed children,and the levels of IL-4 and IL-10 were higher than those of the non-relapsed children(P<0.05);The levels of Th1/Th2,IL-2,and IFN-γ before treat-ment were negatively correlated with CVA recurrence,while IL-4 and IL-10 levels were positively correlated with CVA recurrence(P<0.05).Conclusion:Th immune response index has a certain value in predicting asthma control in children with CVA,and is closely related to the recurrence of CVA.
