Research progress on role of MFG-E8 in regulating function of microglia
10.3969/j.issn.1000-484X.2024.10.033
- VernacularTitle:MFG-E8调节小胶质细胞功能的研究进展
- Author:
Ying DONG
1
;
Gang SU
;
Juan GAO
;
Miao CHAI
;
He WANG
;
Zhenchang ZHANG
Author Information
1. 兰州大学第二医院神经内科,兰州 730030
- Keywords:
Microglia;
MFG-E8;
Neuroprotection;
Tumor-promoting
- From:
Chinese Journal of Immunology
2024;40(10):2214-2218
- CountryChina
- Language:Chinese
-
Abstract:
Microglia are resident immune cells in the central nervous system(CNS),it play an important role in both physio-logical and pathological conditions of the CNS,and can be activated by a variety of physicochemical factors to produce pro-inflammato-ry phenotype(M1 type)and anti-inflammatory phenotype(M2 type).Milk fat globule epidermal growth factor 8(MFG-E8)is closely related to the biological function of microglia,which can regulate microglia neuroprotective effects such as promoting phagocytosis,anti-inflammatory,and inhibiting oxidative stress in CNS related diseases.It also regulates microglia pro-tumor effect,which in turn affects the outcome of the disease.This article reviews the role of targeting MFG-E8 in regulating the function of microglia,and provides a basis for finding therapeutic targets for CNS related diseases in the future.
