Rapeutical effect of safflower polysaccharide on thymic atrophy induced by estradiol in mice
10.3969/j.issn.1000-484X.2024.10.018
- VernacularTitle:红花多糖治疗雌二醇诱导的小鼠胸腺萎缩的药效作用研究
- Author:
Ben CAI
1
;
Kang YE
;
Wei ZHANG
;
Jiali YAO
;
Zhuoqi XIE
;
Wei HUANG
;
Min LU
Author Information
1. 浙江永宁药业股份有限公司,台州 318020
- Keywords:
Safflower polysaccharide;
Thymic atrophy;
Estradiol;
Therapeutical effect
- From:
Chinese Journal of Immunology
2024;40(10):2130-2134
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate efficacy of safflower polysaccharide in treatment of thymic atrophy induced by estradiol in mice.Methods:A total of 75 female ICR mice were divided into 5 groups:control group,model group,ubenimex group,SPS high dose group,SPS low dose group.Except for control group,each group was given intraperitoneal injection of estradiol benzoate every other day for 6 times.Treatment group began administration 24 h after the last parenteral administration,once a day for 10 days.Mice were sacrificed 24 hours after the last administration,and body weight,immune organ index,MDA and GST levels in plasma,periph-eral blood cells and T cells changes were observed,thymus tissue was stained by HE staining and TUNEL cell apoptosis staining,and thymus output capacity was detected.Results:Both high and low doses of safflower polysaccharide significantly improved thymus index(P<0.05)in mice,increased leukocytes level in peripheral blood(P<0.05),proportions of CD3+CD4+T,CD3+CD8+T cells(P<0.05)and CD4+T/CD8+T,improved thymus tissue damage.High dose of safflower polysaccharide could significantly reduce apoptosis in thymus tissue and enhance thymus output.Conclusion:Safflower polysaccharide has a certain therapeutic effect on estradiol-induced thymus atrophy in mice.
