RNA epigenetic modification of immune cells
10.3969/j.issn.1000-484X.2024.09.001
- VernacularTitle:免疫细胞的RNA表观遗传修饰
- Author:
Xiaohan SONG
1
;
Huabing LI
;
Jing ZHOU
Author Information
1. 上海交通大学医学院,上海市免疫学研究所,上海交通大学医学院附属瑞金医院-上海市免疫学研究所免疫与疾病研究中心,上海交通大学医学院-耶鲁免疫代谢研究院,上海 200025
- Keywords:
RNA modification;
Immune cells;
Post-transcriptional regulation;
Immunoregulation
- From:
Chinese Journal of Immunology
2024;40(9):1793-1802
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the rapid advancement of biotechnology has shifted the focus of epigenetic research towards RNA modifications,which play pivotal roles across a diverse range of physiological and pathological processes,particularly in regulating the immune system.As a highly complex and precise regulatory network,the immune system involves the synergistic action of multiple im-mune cells to maintain the immune homeostasis.RNA epigenetic modification plays a crucial role in modulating the development and function of immune cells by influencing different metabolic processes of RNA.This review aims to provide a comprehensive overview of the functions and corresponding regulatory mechanisms of six RNA modifications:m6A,m1A,m5C,m7G,ac4C,and A-to-I editing in immune cells,and further explore their potential roles in complex diseases such as autoimmune diseases and tumors,in order to pro-vide new ideas and strategies for the prevention and treatment of immune-related diseases.
