Advances in mechanism and reversal of TOX-mediated T cell exhaustion
10.3969/j.issn.1000-484X.2024.08.030
- VernacularTitle:TOX介导T细胞耗竭的机制及其逆转研究
- Author:
Shuxin HUANG
1
;
Yangqiu LI
;
Shaohua CHEN
Author Information
1. 暨南大学基础医学与公共卫生学院血液学研究所,广州 510632
- Keywords:
TOX;
T cell exhaustion;
Tumor immunotherapy
- From:
Chinese Journal of Immunology
2024;40(8):1761-1765
- CountryChina
- Language:Chinese
-
Abstract:
Thymocyte selection-associated HMG box(TOX)is a DNA-binding transcription factor that involved in the deve-lopment of immune cells.Several studies have shown that TOX is a critical regulator of T cell exhaustion,and associated with the de-velopment of tumorigenesis,suggesting that TOX may be a potential immune biomarker and target for immunotherapy for malignant tu-mors.In this review,we review the molecular mechanisms and reversals of TOX mediated T cell depletion and provide evidence for the design of more accurate tumor immunotherapy strategies based on TOX.
