Application and prospect analysis of high-throughput TCR immune repertoire technology in AIDS
10.3969/j.issn.1000-484X.2024.07.037
- VernacularTitle:高通量TCR免疫组库技术在艾滋病中的应用及前景分析
- Author:
Yingke REN
1
;
Jie LI
;
Qianlei XU
;
Qiang LI
;
Lu WANG
;
Feng SANG
Author Information
1. 河南中医药大学,郑州 450000
- Keywords:
High-throughput immune repertoire sequencing technology;
HIV;
AIDS
- From:
Chinese Journal of Immunology
2024;40(7):1565-1568,封3
- CountryChina
- Language:Chinese
-
Abstract:
T cell receptors(TCR)immune repertoire is sum of all TCR in body,and diversity of TCR immune repertoire is closely related to HIV recognition and immune escape.High-throughput immune repertoire sequencing technology is able to detect and analyze all sequences of TCR immune repertoire,truly reflect genetic information of all TCR,and comprehensively reveal complexity and diversity of TCR immune repertoire.Analysis of changes in TCR immune group database of HIV patients through high-throughput sequencing technology can monitor their diagnosis and treatment,disease progression and prognosis,and can also contribute to vaccine development,latent reservoir clearance and clinical efficacy evaluation,so as to provide a theoretical basis for enriching prevention and treatment ideas and targets of HIV/AIDS.
