Research progress on immune mechanism of inflammatory bowel disease based on organoid technology

VernacularTitle:基于类器官的炎症性肠病免疫机制研究进展
Author: Yuan CHEN ¹ ; Qian HUANG ; Wu JI
Author Information

1. 南京大学医学院附属金陵医院(东部战区总医院)全军普通外科研究所,南京 210002
Keywords: Inflammatory bowel disease; Organoid; Mucosal immunity; Immune mechanism
From: Chinese Journal of Immunology 2024;40(7):1519-1524
CountryChina
Language:Chinese
Abstract: Inflammatory bowel disease(IBD),mainly containing Crohn's disease(CD)and ulcerative colitis(UC),is a kind of chronic idiopathic disease.The dysregulated mucosal immune response of IBD has been shown to be an important feature of disease progression.Its pathogenesis is characterized by the abnormal function of innate and specific immune associated with mucosal barrier,immune cells,cytokines and microbial homeostasis.Intestinal 3D organoids give rise to all types of cells of intestinal epithelium,pro-viding a promising model for simulating the original immune microenvironment of IBD in vitro.After briefly introducing the method of constructing an organoid model for IBD,this article reviews the progress of immune mechanism and immunotherapy of IBD under the organoid model.