Analysis of the effect of butorphanol combined with parecoxib sodium on patient-controlled intravenous analgesia after uvulo-palato-pharyngo-plasty
- VernacularTitle:布托啡诺复合帕瑞昔布钠在悬雍垂腭咽成形术后自控镇痛中的效果分析
- Author:
Lang XIONG
1
;
Yuan-Yuan WEI
;
Zhi-Jun YANG
Author Information
- Keywords: butorphanol; paroxicib sodium; uvulo-palato-pharyngo-plasty; patient-controlled intravenous analgesia; effect
- From: Journal of Regional Anatomy and Operative Surgery 2024;33(11):941-944
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the effect of butorphanol combined with parecoxib sodium on patient-controlled intravenous analgesia(PCIA)after uvulo-palato-pharyngo-plasty(UPPP).Methods Eighty patients who were admitted to our hospital from October 2021 to May 2023 and planned to receive UPPP were collected,and they were randomly assigned to the paroxicib sodium group(D group),the butorphanol low-dose group(B1 group),the butorphanol medium dose group(B2 group),and the butorphanol high-dose group(B3 group),with 20 cases in each group.Patients in the D group received 40 mg of paroxycoxib sodium with 0.9% sodium chloride injection for analgesia,and patients in the B1 group,the B2 group,and the B3 group were combined with 3.0 μg·kg-1·h-1,4.0 μg·kg-1·h-1,and 5.0 μg·kg-1·h-1 of butorphanol respectively on the basis of D group.The heart rate and mean arterial pressure before PCIA and 2 hours,12 hours,24 hours,and 48 hours after PCIA were compared among the four groups;the pain visual analogue scale(VAS)score,Ramsay score 2 hours,12 hours,24 hours,and 48 hours after PCIA were compared among the four groups;the number of PCIA compression,and incidence of adverse reactions were recorded.Results There was no statistically significant difference in the heart rate or mean arterial pressure before PCIA and 2 hours,12 hours,24 hours,and 48 hours after PCIA among the four groups(P>0.05).Compared with the D group,the VAS scores 2 hours,12 hours,24 hours,and 48 hours after PCIA of the B1,B2,and B3 groups significantly decreased(P<0.05),and the higher the dose of butorphanol,the lower the VAS score(P<0.05).Compared with the D group,the Ramsay scores 2 hours,12 hours,24 hours,and 48 hours after PCIA of the B1,B2,and B3 groups obviously increased(P<0.05),and the higher the dose of butorphanol,the higher the Ramsay score(P<0.05).The total incidence of adverse reactions in the B3 group was obviously higher than that in the D group,the B1 group,and the B2 group(P<0.05).Compared with the D group,patients in the B1,B2,and B3 groups had significantly fewer PCIA compressions(P<0.05),and the higher the dose of butorphanol,the fewer the PCIA compressions(P<0.05).Conclusion The effect of butorphanol combined with parecoxib sodium in PCIA after UPPP is better,and combined with 4.0 μg·kg-1·h-1 parecoxib sodium has more significant analgesic effect and higher safety.
