Association of the myeloperoxidase-463G->A polymorphism with development of atrophy in Helicobacter pylori-infected gastritis.
- Author:
Man Yong LEE
1
;
Im Hwan ROE
;
Na Young KWON
;
Ki Chul SHIN
;
Hyo Shik CHANG
;
Seung Ho SONG
;
Seung Woo NAM
;
Jung Won KIM
;
Na Hye MYUNG
;
Ji Hyun SHIN
Author Information
1. Department of Internal Medicine, College of Medicine, Dankook University Cheonan, Korea. nayana@dankook.ac.kr
- Publication Type:Original Article
- Keywords:
Myeloperoxidase;
Host factor;
H. pylori;
Polymorphism;
Atrophy
- MeSH:
Atrophy*;
Biopsy;
Colon;
Gastric Mucosa;
Gastritis*;
Gastritis, Atrophic;
Genotype;
Helicobacter pylori;
Helicobacter*;
Humans;
Inflammation;
Neutrophil Infiltration;
Neutrophils;
Peroxidase;
Polymorphism, Genetic
- From:Korean Journal of Medicine
2003;64(3):260-267
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Helicobacter pylori (H. pylori) infection is characterized by extensive infiltration of neutrophils and induces atrophic gastritis, however, the host factors governing the development of atrophy have not been defined. Myeloperoxidase (MPO) in neutrophils amplifies the oxidative potential, thus MPO is suspected to play a role in H. pylori-induced gastric atrophy. Therefore, we explored the association of host MPO genetic polymorphism with atrophic gastritis upon H. pylori infection. METHODS: Biopsy specimens taken from the gastric mucosa were examined histologically in 127 patients. The PCR-RFLP assay was used to characterize MPO genotypes. RESULTS: The distributions of MPO genotypes were MPO (G/G) 81.9% and MPO (G/A) 18.1%. None of MPO (A/A) genotype was observed in 127 patients studied. The degree of active inflammation increased with the increase in H. pylori colonization. A strong positive correlation between the levels of neutrophil infiltration and gastric atrophy was found only in MPO (G/G) but not in MPO (G/A) genotype. CONCLUSION: MPO G/G genotype may be a critical determinant in the pathogenesis of atrophic gastritis subsequent to H. pylori infection.
