Research progress in the effect of SARS-CoV-2 infection on Alzheimer's disease
10.12138/j.issn.1671-9638.20246083
- VernacularTitle:新型冠状病毒感染对阿尔茨海默病影响的研究进展
- Author:
Kang WANG
1
;
Yan ZHANG
;
Hui ZHAO
;
Long SHAO
;
Ling-Ling FENG
;
Tong ZHAO
Author Information
1. 山东第一医科大学第二附属医院神经内科,山东 泰安 271000
- Keywords:
severe acute respiratory syndrome coronavirus 2;
Alzheimer's disease;
immune response;
inflamma-tion;
cell aging;
autophagy;
oxidative stress
- From:
Chinese Journal of Infection Control
2024;23(11):1450-1455
- CountryChina
- Language:Chinese
-
Abstract:
The global morbidity and mortality of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection are gradually decreasing,but the elderly people are still at higher risk of death than the general population,especially for those with Alzheimer's disease(AD).AD is a slowly progressing degenerative disease of the nervous system,and is the most common type of dementia.Its neuropathological features include overproduction and clea-rance imbalance of amyloid β-protein and overphosphorylated tau protein leading to neurofibrillary tangle.People with AD are more susceptible to be infected with SARS-CoV-2,likewise,the virus can also cause AD in those who are infected.After SARS-CoV-2 infection,it affects AD through immune response,inflammatory response,cell aging,DNA damage reaction,autophagy disorder,choroidal homeostasis disorder,over-activation of renin-angio-tensin system,and oxidative stress.This article mainly reviews the research progress in the effect of SARS-CoV-2 infection on AD.
