Research advances in receptors related to interaction between SARS-CoV-2 S protein and host cells
10.12138/j.issn.1671-9638.20246284
- VernacularTitle:SARS-CoV-2 S蛋白与宿主细胞相互作用的相关受体研究进展
- Author:
Xiao-Min FANG
1
;
Xing-Jian LIU
;
Rui-Gang ZHANG
Author Information
1. 广东医科大学基础医学院生理学教研室,广东湛江 524000
- Keywords:
SARS-CoV-2;
S protein;
receptor;
interaction
- From:
Chinese Journal of Infection Control
2024;23(10):1326-1332
- CountryChina
- Language:Chinese
-
Abstract:
Since the outbreak of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection at the end of 2019,its global research has become a hot spot.The tendency of coronavirus infection mainly depends on the ability of spike protein(S protein)binding to receptors on the cell surface.S protein and its receptor binding domain(S-RBD)not only play a key role in the binding of virus to host cells and the entry of virus into cells,they can also bind to host cell surface receptors such as angiotensin-converting enzyme 2(ACE2),Toll-like receptor(TLRs),cluster of differentiation(CD)147,and neuropilin 1(NRP-1),activating different signaling pathways,thus promo-ting virus to invade host cells and trigger a series of pathogenic processes such as inflammation.Therefore,it is of great significance to study receptors involving in the interaction between S protein and host cells.This article re-views the receptors related to the interaction between S protein and host cells,so as to provide theoretical basis for the prevention and treatment of SARS-CoV-2 infection.
