Research progress in Clostridium perfringens toxin vaccines
10.12138/j.issn.1671-9638.20245387
- VernacularTitle:产气荚膜梭菌毒素疫苗研究进展
- Author:
Dong WANG
1
;
Si-Yu ZHANG
;
Ya-Wen DING
;
Jin ZENG
Author Information
1. 宁夏大学西部特色生物资源保护与利用教育部重点实验室,宁夏回族自治区 银川 750021;宁夏大学生命科学学院,宁夏回族自治区 银川 750021
- Keywords:
Clostridium perfringens;
toxin;
epidemiology;
toxoid vaccine;
recombinant vaccine
- From:
Chinese Journal of Infection Control
2024;23(7):910-917
- CountryChina
- Language:Chinese
-
Abstract:
Clostridium perfringens is an important foodborne pathogen that causes intestinal infections and tissue necrosis in both human and animals.A variety of exotoxins it produces are lethal.The increasing demand for ratio-nal use of antimicrobial agents and healthy farming make the implementation of vaccination critically important.H owever,traditional Clostridium perfringens exotoxin vaccines may have problems such as inconsistent efficacy,residual toxins and formaldehyde,raising concerns about the safety of these vaccines.This article systematically in-troduces the latest research progress in traditional toxoid vaccine,genetically engineered recombinant vaccines,and epitope peptide vaccines designed based on reverse vaccinology and immunoinformatics for Clostridium perfringens,providing new ideas for the development and preparation of effective and safe novel Clostridium perfringens toxin vaccines.
