Linezolid-induced fatal lactic acidosiss:an adverse reaction easily confu-sed with septic shock
10.12138/j.issn.1671-9638.20245111
- VernacularTitle:利奈唑胺诱导致命性乳酸中毒:一种极易混淆为脓毒性休克的不良反应
- Author:
Ran ZHU
1
;
Shao-Wan YANG
;
Xing-Han TIAN
;
Xiao-Li LI
;
Yan LIU
Author Information
1. 滨州医学院第二临床医学院,山东 烟台 264199
- Keywords:
linezolid;
multidrug resistance;
lactic acidosis;
septic shock
- From:
Chinese Journal of Infection Control
2024;23(7):897-900
- CountryChina
- Language:Chinese
-
Abstract:
Clinical data of 3 patients with linezolid-induced lactic acidosis treated in 2 hospitals in Beijing and Shandong were retrospectively analyzed,and relevant literatures at home and abroad were retrieved.The pathogene-sis,risk factors,clinical manifestations,and treatment scheme were valuated.Three patients received linezolid anti-infection treatment due to their disease condition.At different phases of treatment,they developed lactic acidosis that was difficult to be explained with septic shock.After discontinuing linezolid and receiving bedside continuous veno-venous hemofiltration(CVVH)treatment,patient's blood lactate levels decreased significantly.It is clinically diagnosed linezolid-induced lactic acidosis finally,but the initial diagnosis was septic shock by all doctors.After ac-tive treatment,2 patients recovered and 1 patient died.Linezolid-induced lactic acidosis is easily to be misdiagnosed as septic shock.Clinicians should enhance their understanding and recognition of the early diagnosis of the adverse reactions,take effective measures,so as to improve patient prognosis.
