A retrospective study on clinical efficacy of glucocorticoid treatment in 62 elderly patients with moderate COVID-19
10.12138/j.issn.1671-9638.20245398
- VernacularTitle:糖皮质激素治疗中型新型冠状病毒感染高龄老年患者62例临床疗效回顾性研究
- Author:
Ya SUN
1
;
Ding-Jiang PENG
;
Yi-Jun ZHANG
Author Information
1. 广州中医药大学,广东广州 510080;中国人民解放军南部战区总医院干部病房二科,广东广州 510080
- Keywords:
coronavirus disease 2019;
elderly people;
glucocorticoids;
COVID-19;
treatment efficacy
- From:
Chinese Journal of Infection Control
2024;23(6):680-686
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of low-dose and short-course glucocorticoid treatment on moderate coronavirus disease 2019(COVID-19)in elderly patients.Methods Clinical data of patients aged ≥80 years,diag-nosed with COVID-19,and admitted to a hospital from December 9,2022,to February 9,2023 were investigated retrospectively.According to whether low-dose glucocorticoids was administered intravenously after admission,pa-tients were divided into non-hormone usage group and hormone usage group.General information and laboratory test results of two groups of patients were described,changes of patients'conditions within 30 days were observed,and difference in efficacy between the two groups was compared.Results A total of 62 patients were recruited,in-cluding 21 in the non-hormone usage group and 41 in the hormone usage group.The general information and labora-tory test indicators before treatment between two groups of patients showed no statistically significant differences(both P＞0.05).Except hormone usage,there was no statistically significant difference in other treatment methods(all P＞0.05).After treatment with glucocorticoids for 10 days,the clinical manifestations of cough(34.1％vs 66.7％),expectoration(19.5％vs 61.9％),palpitation(4.9％vs 23.8％)and shortness of breath(7.3％vs 28.6％)in the hormone usage group decreased compared with those in the non-hormone usage group,differences were statis-tically significant(all P＜0.05).After 10 days of treatment,compared with patients in the non-hormone usage group,the oxygenation indicator and lymphocyte count of patients in the hormone usage group increased,while the values of C-reactive protein and D-dimer decreased,with statistically significant differences(all P＜0.05).The inci-dence of disease exacerbation in the hormone usage group was lower than that in the non-hormone usage group(14.6％vs 47.6％),difference was statistically significant(x2=7.895,P=0.005).Conclusion Low-dose and short-course systemic glucocorticoid usage in elderly patients with moderate COVID-19 can effectively control the progress of the disease and improve prognosis.
