Diagnosis on central nervous system Coxiella burnetii infectious vasculitis assisted by metagenomic next-generation sequencing technique:one case report
10.12138/j.issn.1671-9638.20244786
- VernacularTitle:宏基因组二代测序技术辅助诊断中枢神经系统贝氏柯克斯体感染性血管炎1例
- Author:
Yan-Shan CAI
1
;
Zi-Fan LIU
Author Information
1. 广州市疾病预防控制中心艾滋病预防控制部,广东广州 510440;广州市疾病预防控制中心广州医科大学公共卫生研究院,广东广州 510440
- Keywords:
Q fever;
Coxiella burnetii;
infectious vasculitis;
metagenomic next-generation sequencing;
mNGS
- From:
Chinese Journal of Infection Control
2024;23(5):628-630
- CountryChina
- Language:Chinese
-
Abstract:
Q fever is a zoonotic disease caused by Coxiella burnetii,with diverse and non-specific clinical manifes-tations.Intracranial infection caused by Coxiella burnetii is rare and is often misdiagnosed and underdiagnosed,leading to poor prognosis in some patients.This article reports a case of central nervous system intracranial infec-tious vasculitis caused by Coxiella burnetii through diagnosis assisted by metagenomic next-generation sequencing(mNGS)technique,indicating that mNGS technique plays an important role in rapid diagnosis of Q fever.After early diagnosis and precise treatment,the prognosis of patient was improved significantly.On this basis,relevant literatures at home and abroad are reviewed to summarize the clinical manifestations as well as diagnosis and treatment experience of intracranial infection caused by Coxiella burnetii,providing reference for domestic and foreign peers.
