Obesity-related glomerulopathy: pathogenesis, pathologic,clinical characteristics and treatment
10.1007/s11684-017-0570-3
- Author:
Xu TIANHUA
1
;
Sheng ZITONG
;
Yao LI
Author Information
1. Department of Nephrology
- Keywords:
obesity-related glomerulopathy;
pathogenesis;
pathologic;
clinical characteristics
- From:
Frontiers of Medicine
2017;11(3):340-348
- CountryChina
- Language:Chinese
-
Abstract:
In light of the rapid increase in the number of obesity incidences worldwide,obesity has become an independent risk factor for chronic kidney disease.Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions.IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluoreseence.ORG-associated glomerulomegaly and focal and segmental glomernlosclerosis can superimpose on other renal pathologies.The mechanisms under ORG are complex,especially hemodynamic changes,inflammation,oxidative stress,apoptosis,and reduced functioning nephrons.These mechanisms synergize with obesity to induce end-stage renal disease.A slow increase of subnephrotic proteinuria (＜ 3.5 g/d) is the most common clinical manifestation of ORG.Several treatment methods for ORG have been developed.Of these methods,renin-angiotensin-aldosterone system blockade and weight loss are proven effective.Targeting mitochondria may offer a novel strategy for ORG therapy.Nevertheless,more research is needed to further understand ORG.
